Birc5 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comBirc5 Polyclonal Antibody for Rat(Rattus norvegicus)

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Birc5 (Gene name),

Baculoviral IAP repeat-containing protein 5 (Protein name ), BIRC5_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Birc5;

Protein name:

Baculoviral IAP repeat-containing protein 5;

Alternative:

Apoptosis inhibitor survivin;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state (By similarity). When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin.

Function:

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7.

Subcellular Location:

Cytoplasm Nucleus Chromosome centromere Cytoplasm cytoskeleton spindle Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.

Protein Attributes:

Sequence length:

142

Sequence:

50:

100:

142:

FLKLDKQRAK | NKIAKETNNK | QKEFEETRRT | VRQSIEQLAA | LR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:64041

Pfam:

PF00653

UniGene:

Rn.54471

SMR:

Q9JHY7

Uniprot:

Q9JHY7

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045h

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045m

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045b

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045p

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045d

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ELISA Kit for Rat Baculoviral IAP repeat-containing protein 5

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E2045r

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CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045d

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CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045b

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96T

CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045p

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96T

CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045r

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CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045m

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96T

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CLIA Kit for Rat Baculoviral IAP repeat-containing protein 5

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U2045h

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96T

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Polyclonal Antibody for Rat Baculoviral IAP repeat-containing protein 5

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P2045Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Baculoviral IAP repeat-containing protein 5

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P2045Rb-h

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Polyclonal Antibody for Rat Baculoviral IAP repeat-containing protein 5

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P2045Rb-m

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Monoclonal Antibody for Rat Baculoviral IAP repeat-containing protein 5

Protein for Rat Baculoviral IAP repeat-containing protein 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of rat survivin."
Chen D. , Cao G. , Chen J.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.

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